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Naoto Hoshi

University of California, USA

Title: Palmitoylation of neural proteins might be a link between lipid metabolism and anti-convulsant action

Biography

Biography: Naoto Hoshi

Abstract

We recently found that valproic acid suppresses palmitoylation of neural proteins including AKAP5 (AKAP79/150). Reduced AKAP5 palmitoylation disrupted regulation of the M-current, which is generated by neural Kv7 channel family. Various neurotransmitters that activate Gq-coupled receptors suppress M-current and increase neuronal excitability. We show that palmitoylation is required for receptor-induced M-current supprssion. Similar disruption of M-current suppression was observed by inhibition of acyl-CoA synthetase. These results might fill in a gap between lipid metabolism and its anticonvalsant action.